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Symbol
Name
ID

Cdk6
cyclin dependent kinase 6
MGI:1277162

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Mouse Phenotypes

decreased thymocyte apoptosis

increased T cell apoptosis

decreased T cell proliferation

abnormal thymus morphology

thymus cortex atrophy

enlarged thymus

small thymus

thymus atrophy

thymus hypoplasia

decreased thymocyte number

decreased DN1 thymic pro-T cell number

decreased DN2 thymocyte number

decreased DN4 thymocyte number

increased thymocyte number

increased DN1 thymic pro-T cell number

increased DN3 thymocyte number

abnormal thymocyte activation

abnormal hematopoietic system morphology/development

abnormal definitive hematopoiesis

abnormal lymphopoiesis

abnormal T cell differentiation

decreased double-negative T cell number

increased double-negative T cell number

decreased double-positive T cell number

decreased megakaryocyte cell number

abnormal erythrocyte morphology

decreased erythrocyte cell number

increased mean corpuscular hemoglobin

increased mean corpuscular hemoglobin concentration

increased mean corpuscular volume

increased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased single-positive T cell number

decreased leukocyte cell number

decreased hematopoietic stem cell number

increased hematopoietic stem cell number

abnormal spleen morphology

abnormal spleen red pulp morphology

small spleen

spleen hypoplasia

abnormal hematopoietic stem cell physiology

Availability

Mouse Genotype

Cdk6^{tm1b(EUCOMM)Wtsi}/Cdk6^{tm1b(EUCOMM)Wtsi}

Cdk6^tm1Bbd/Cdk6^tm1Bbd

Cdk6^tm1Phin/Cdk6^tm1Phin

Cdk6^tm2.1Phin/Cdk6^tm2.1Phin

Cdk6^tm3.1Phin/Cdk6^tm3.1Phin

Cdk6^tm4.1Phin/Cdk6^tm4.1Phin

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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